Dr Tientcheu's research focuses on understanding how human host diversity and Mycobacterium tuberculosis complex (MTBC) genetic variation shape immune responses, disease progression, and treatment outcomes in tuberculosis. He is particularly interested in host–pathogen interactions, strain-specific immunopathology, and the development of host-directed therapies (HDTs), including the repurposing of tyrosine kinase inhibitors and antioxidant-based interventions. Using integrated immunological, mycobacteriological, genomic, and imaging approaches, his work aims to inform TB treatment and vaccine strategies relevant to African populations. He also has strong interests in post-TB lung disease, diagnostics, and building sustainable research capacity at the London School of Hygiene & Tropical Medicine and partner institutions in Africa.