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Dr

Chris Smith

Clinical Associate Professor

Clinical Research

Orcid identifier0000-0001-9238-3202
  • Clinical Associate Professor
    Clinical Research
  • London School of Hygiene & Tropical Medicine, Department of Clinical Research, Keppel Street, London, WC1E 7HT, United Kingdom
  • Nagasaki University, School of Tropical Medicine & Global Health, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan

BIO

I am a UK-trained general practitioner and clinical academic in a joint position between the London School of Hygiene & Tropical Medicine (LSHTM) and Nagasaki University, Japan. My research focuses on infectious and tropical diseases, particularly in Southeast Asia, using clinical epidemiological approaches including randomised controlled trials, observational studies and evidence synthesis.

 

I have worked in the NHS and in Cambodia, Laos, the Philippines, Vietnam and Malaysia, as well as with Médecins Sans Frontières in Uganda and as an expedition doctor in Belize. Since starting my joint LSHTM-Nagasaki University position in 2017, much of my work has focused on developing long-term research and educational collaborations between the two institutions and clinical and academic partners across Southeast Asia. One of the most rewarding aspects of this work has been the opportunity to work with excellent colleagues in Japan, the Philippines, Malaysia and elsewhere in Southeast Asia, and to develop partnerships that have grown over many years.

 

A major current research focus is leptospirosis. Working with colleagues and postgraduate researchers at Nagasaki University, LSHTM and partner institutions, we have developed a programme spanning epidemiology, diagnosis, evidence synthesis and treatment. This has included Cochrane reviews of antibiotics, antibiotic prophylaxis and corticosteroids, and the development of a Core Outcome Set for leptospirosis trials led by PhD student Nathaniel Lee. We are now moving towards interventional research and multicentre clinical trials in the Philippines.

 

Two recently awarded grants support the next stage of this programme. Funding from the Japan Society for the Promotion of Science (JSPS; KAKENHI) supports the run-in phase of a randomised controlled trial of adjunctive corticosteroids for moderate-to-severe leptospirosis in the Philippines, alongside development of clinical trial capacity. A Wellcome Trust trial development award supports further development towards a definitive multicentre trial. This work involves collaboration with clinical and academic partners in the Philippines, Japan and the UK, as well as wider Japanese research initiatives including AMED-supported ARISE and SCARDA programmes.

 

My wider infectious disease research includes rabies, diphtheria, measles, typhoid fever, dengue, COVID-19 and undifferentiated febrile illness. I also contribute to a SATREPS programme funded by AMED and JICA investigating zoonotic Plasmodium knowlesi malaria in Sabah, Malaysia, including evaluation of a community risk-education intervention. Earlier research included digital health and reproductive health, including randomised controlled trials of mobile phone-based interventions for contraception.

 

Since starting my joint LSHTM–Nagasaki University position in 2017, I have contributed to a substantial programme of collaborative research, postgraduate education and research capacity development. I have supervised or co-supervised five students through the Nagasaki University–LSHTM Joint PhD programme, three of whom have completed their PhDs, alongside PhD and Master's students working across a broad range of infectious disease and global health topics. These collaborations have generated a substantial body of peer-reviewed publications and have increasingly developed from individual research projects into larger collaborative programmes, clinical trials and research networks.

 

Alongside my research, I have played a major role in developing postgraduate tropical medicine education at Nagasaki University. I established the Diploma of Tropical Medicine & Hygiene (DTM&H), Philippines Tropical Medicine Course (PTMC) and Certificate of Tropical Medicine (CTM), and continue to direct these programmes. I am also Course Director of the Nagasaki University Master of Tropical Medicine. I teach and supervise Master's and doctoral students across a range of clinical and infectious disease topics and contribute to the wider academic partnership between Nagasaki University and LSHTM.

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE APPOINTMENTS

  • Clinical Associate Professor
    London School of Hygiene & Tropical Medicine, Department of Clinical Research, London, United Kingdom1 Sep 2017 - present
  • Clinical Assistant Professor
    London School of Hygiene & Tropical Medicine, Department of Population Health, London, United Kingdom19 Nov 2016 - 31 Aug 2017
  • Clinical Research Fellow / MRC Population Health Scientist
    London School of Hygiene & Tropical Medicine, Department of Population Health, London, United Kingdom1 Apr 2014 - 18 Nov 2016

ACADEMIC POSITIONS

  • Professor
    Nagasaki University, School of Tropical Medicine and Global Health, Japan1 Oct 2017 - present
  • NIHR Clinical Research Fellow
    Imperial College London, Department of Primary Care and Public Health, London, United Kingdom1 Sep 2010 - 31 Aug 2012
  • Honorary Clinical Research Fellow
    Imperial College London, Department of Primary Care and Public Health, London, United Kingdom1 Sep 2012 - 27 Jul 2017

NON-ACADEMIC POSITIONS

  • Medical Staff Bank Doctor
    Guy's and St Thomas' NHS Foundation Trust, Emergency Department, London, United Kingdom18 Apr 2019 - present
  • Consultant - COVID-19 response
    World Health Organization Regional Office for the Western Pacific, Port Moresby, Papua New Guinea1 Nov 2020 - 22 Dec 2020
  • Lead Investigator, MObile Technology for Improved Family Planning (MOTIF) project
    Marie Stopes International, Phnom Penh, Cambodia1 Oct 2012 - 31 Dec 2013
  • International Fellow to the ‘Improving Global Health through Leadership Development’ scheme
    NHS South Central, Battambang, Cambodia1 Sep 2008 - 3 Jun 2009
  • GP Vocational Training Scheme
    National Health Service (NHS), Portsmouth, United Kingdom1 Feb 2007 - 31 Jul 2008
  • Medical Doctor
    Médecins Sans Frontières, Kitgum, Uganda1 Sep 2005 - 3 Mar 2006
  • Cardiology Registrar
    Portsmouth Hospitals NHS Trust, Cardiology, Portsmouth, United Kingdom1 Nov 2004 - 31 Aug 2005
  • Senior House Office Medical Rotation
    Portsmouth Hospitals NHS Trust, Medicine, Portsmouth, United Kingdom1 Aug 2002 - 31 Oct 2004
  • Expedition Doctor
    Trekforce Expeditions, Belize8 Feb 2002 - 14 Apr 2002
  • Senior House Officer in Accident & Emergency
    Royal Bournemouth Hospital, Bournemouth, United Kingdom1 Aug 2001 - 31 Jan 2002
  • Pre-Registration House Officer, Surgery
    Wrexham Maelor Hospital, Surgery, Wrexham, United Kingdom1 Feb 2001 - 31 Jul 2001
  • Pre-Registration House Officer, Medicine
    Prince Charles Hospital, Cardiology, Merthyr Tydfil, United Kingdom1 Aug 2000 - 31 Jan 2001

DEGREES

  • PhD
    London School of Hygiene and Tropical Medicine, London, United Kingdom23 Nov 2012 - 24 Feb 2017
  • MSc Public Health in Developing Countries (PHDC) - with Distinction
    London School of Hygiene & Tropical Medicine, London, United Kingdom28 Sep 2009 - 1 Nov 2011
  • MBBCh - with Merit
    Cardiff University, Cardiff, United Kingdom1 Sep 1995 - 22 Jul 2000

CERTIFICATIONS

  • Diploma in Tropical Medicine & Hygiene (DTM&H) - East African Partnership
    London School of Hygiene & Tropical Medicine, United Kingdom23 Nov 2017 - present
  • Diploma of the London School of Hygiene and Tropical Medicine (DLSHTM)
    London School of Hygiene & Tropical Medicine, London, United Kingdom10 Mar 2012 - present
  • Diploma of the Faculty of Sexual and Reproductive Healthcare (DFSRH)
    Faculty of Sexual and Reproductive Health of the Royal College of Obstetricians and Gynaecologists, London, United Kingdom31 Oct 2009 - present
  • Diploma of the Royal College of Obstetricians and Gynaecologists (DRCOG)
    Royal College of Obstetricians and Gynaecologists, London, United Kingdom12 Apr 2008 - present
  • Certificate of Completion of Training (CCT) in General Practice
    Postgraduate Medical Education and Training Board (PMETB), United Kingdom31 Jul 2008 - present
  • Member of the Royal Colleges of Physicians of the United Kingdom (MRCP)
    Royal College of Physicians, London, United Kingdom29 Jul 2004 - present
  • Member of the Royal College of General Practitioners (RCGP)
    Royal College of General Practitioners, London, United Kingdom2 Sep 2008 - present
  • Good Clinical Practice (GCP)
    NIDA Clinical Trials Network19 Mar 2023 - 19 Mar 2026

LANGUAGES

  • English
    Can read, write, speak, understand and peer review

RESEARCH CENTRES

  • Antimicrobial Resistance Centre
  • Health in Humanitarian Crises Centre

REGIONS & COUNTRIES

  • East Asia & Pacific (developing only)
  • Cambodia
  • Philippines
  • Japan
  • United Kingdom
  • Zambia

TOPICS & DISCIPLINES