I trained in epidemiology, and came to LSHTM in 2006 for my PhD, working primarily on the molecular epidemiology of Tuberculosis. After spending three years working on field studies in North Malawi, I moved back to London in 2012 to work in TB modelling, and joined the LSHTM TB modelling group which I now co-lead. Between 2014 and 2019 led the development and implementation of the TIME model to support countries in their TB policy decision-making. In recent years my focus has been the spectrum of Mtb infection and TB disease, using historical and contemporary data to better understand the individual, population and policy consequences of appropriately considering the spectrum of TB. I also have an interest in the many structural determinants of TB, including nutrition, climate health and poverty.